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Chemical Structure : MK-0674
Catalog No.: PC-62961Not For Human Use, Lab Use Only.
MK-0674 (MK 0674) is a potent, selective, reversible and orally active cathepsin K inhibitor with IC50 of 1 nM.
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MK-0674 (MK 0674) is a potent, selective, reversible and orally active cathepsin K inhibitor with IC50 of 1 nM.
MK-0674 exhibits long half-life in pre-clinical species, show stereoselective epimerization of the alcohol stereocenter via an oxidation/reduction cycle.
| M.Wt | 527.51 | |
| Formula | C26H27F6N3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Isabel E, et al. Bioorg Med Chem Lett. 2010 Feb 1;20(3):887-92.
2. Murphy DJ, et al. J Am Chem Soc. 2015 Sep 9;137(35):11230-3.
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