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MK-0674

Chemical Structure : MK-0674

CAS No.: 887781-62-6

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MK-0674 (MK0674, MK 0674)

Catalog No.: PC-62961Not For Human Use, Lab Use Only.

MK-0674 (MK 0674) is a potent, selective, reversible and orally active cathepsin K inhibitor with IC50 of 1 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    MK-0674 (MK 0674) is a potent, selective, reversible and orally active cathepsin K inhibitor with IC50 of 1 nM.
    MK-0674 exhibits long half-life in pre-clinical species, show stereoselective epimerization of the alcohol stereocenter via an oxidation/reduction cycle.

    Physicochemical Properties

    M.Wt 527.51
    Formula C26H27F6N3O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (S)-N-(1-cyanocyclopropyl)-2-(((S)-1-(4'-((R)-2,2-difluoro-1-hydroxyethyl)-[1,1'-biphenyl]-4-yl)-2,2,2-trifluoroethyl)amino)-4-fluoro-4-methylpentanamide

    References

    1. Isabel E, et al. Bioorg Med Chem Lett. 2010 Feb 1;20(3):887-92.

    2. Murphy DJ, et al. J Am Chem Soc. 2015 Sep 9;137(35):11230-3.

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