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MK-0752

Chemical Structure : MK-0752

CAS No.: 471905-41-6

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MK-0752 (MK0752;MK 0752)

Catalog No.: PC-42758Not For Human Use, Lab Use Only.

MK-0752 (MK0752) is a potent γ-secretase inhibitor that shows dose-dependent reduction of Aβ40 with an IC50 of 5 nM in human SH-SY5Y cells, inhibits Notch signaling.

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5 mg $128 In stock
10 mg $188 In stock
25 mg $288 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

MK-0752 (MK0752) is a potent γ-secretase inhibitor that shows dose-dependent reduction of Aβ40 with an IC50 of 5 nM in human SH-SY5Y cells, inhibits Notch signaling.

Physicochemical Properties

M.Wt 442.9038
Formula C21H21ClF2O4S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Cyclohexanepropanoic acid, 4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)-, cis-

References

1. Cook JJ, et al. J Neurosci. 2010 May 12;30(19):6743-50.

2. Previs RA, et al. Clin Cancer Res. 2015 Mar 1;21(5):955-61.

3. Brana I, et al. Br J Cancer. 2014 Nov 11;111(10):1932-44.

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