MK-0873 | PDE4 inhibitor | Probechem Biochemicals

Chemical Structure : MK-0873

MK-0873 (MK0873)

Catalog No.: PC-28123Not For Human Use, Lab Use Only.

MK-0873 is a potent and orally active phosphodiesterase 4 (PDE4) inhibitor with IC50 of 6.7 nM (PDE4A), inhibits LPS-induced TNF-α production in human whole blood with IC50 of 178 nM.

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Biological Activity

MK-0873 is a potent and orally active phosphodiesterase 4 (PDE4) inhibitor with IC50 of 6.7 nM (PDE4A), inhibits LPS-induced TNF-α production in human whole blood with IC50 of 178 nM.

Physicochemical Properties

M.Wt	422.44
Formula	C25H18N4O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	3-((3-(3-(cyclopropylcarbamoyl)-4-oxo-1,8-naphthyridin-1(4H)-yl)phenyl)ethynyl)pyridine 1-oxide

References

1. Guay D, et al. Bioorg Med Chem Lett. 2008 Oct 15;18(20):5554-8.

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MK-0873 (MK0873)

Biological Activity

Physicochemical Properties

References

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