MK-0941 (MK0941) is a potent, orally active Glucokinase (GK) activator with EC50 of 0.240 and 0.065 uM in 2.5 and 10 mM glucose, respectively.
MK-0941 increases insulin secretion by 17-fold and glucose uptake up to 18-fold, respectively, in isolated rat islets of Langerhans and hepatocytes at 10 uM。
MK-0941 exhibits strong glucose-lowering activity in rodent models of type 2 diabetes and healthy dogs.
