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Chemical Structure : MK-1256
Catalog No.: PC-49223Not For Human Use, Lab Use Only.
MK-1256 (MK1256) is a potent, selective cathepsin K (Cat K) inhibitor with IC50 of 0.62 nM, >1100-fold selectivity over Cat B, L, S, C, H, Z, and V, 110-fold over Cat F.
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MK-1256 (MK1256) is a potent, selective cathepsin K (Cat K) inhibitor with IC50 of 0.62 nM, >1100-fold selectivity over Cat B, L, S, C, H, Z, and V, 110-fold over Cat F.
MK-1256 is efficacious in monkey model of osteoporosis.
| M.Wt | 563.417 | |
| Formula | C23H23Cl2F3N4O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Robichaud J, et al. J Med Chem. 2008 Oct 23;51(20):6410-20.
2. Ma B, et al. Naunyn Schmiedebergs Arch Pharmacol. 2017 Apr;390(4):435-441.
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