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MK-1256

Chemical Structure : MK-1256

CAS No.: 919109-76-5

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MK-1256 (MK1256)

Catalog No.: PC-49223Not For Human Use, Lab Use Only.

MK-1256 (MK1256) is a potent, selective cathepsin K (Cat K) inhibitor with IC50 of 0.62 nM, >1100-fold selectivity over Cat B, L, S, C, H, Z, and V, 110-fold over Cat F.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    MK-1256 (MK1256) is a potent, selective cathepsin K (Cat K) inhibitor with IC50 of 0.62 nM, >1100-fold selectivity over Cat B, L, S, C, H, Z, and V, 110-fold over Cat F.
    MK-1256 is efficacious in monkey model of osteoporosis.

    Physicochemical Properties

    M.Wt 563.417
    Formula C23H23Cl2F3N4O3S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (1R,2R)-5,5-Dichloro-N-(1-cyanocyclopropyl)-2-[4-[4-(methylsulfonyl)phenyl]-1-(2,2,2-trifluoroethyl)-1H-pyrazol-3-yl]cyclohexanecarboxamide

    References

    1. Robichaud J, et al. J Med Chem. 2008 Oct 23;51(20):6410-20.

    2. Ma B, et al. Naunyn Schmiedebergs Arch Pharmacol. 2017 Apr;390(4):435-441.

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