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Chemical Structure : MK-1832
Catalog No.: PC-62815Not For Human Use, Lab Use Only.
MK-1832 is a potent, selective Kv1.5 inhibitor with IC50 of 86 nM, exhibits improved selectivity for IKur over IKs (>3000-fold) compares with MK-0448 (70-fold).
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MK-1832 is a potent, selective Kv1.5 inhibitor with IC50 of 86 nM, exhibits improved selectivity for IKur over IKs (>3000-fold) compares with MK-0448 (70-fold).
MK-1832 also exhibits an improved preclinical pharmacokinetic profile.
MK-1832 is a P-gp substrate and exhibits limited CNS exposure in vivo.
| M.Wt | 422.309 | |
| Formula | C23H17Cl2N3O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Wolkenberg SE, et al. Bioorg Med Chem Lett. 2017 Feb 15;27(4):1062-1069.
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