MK-1832 |CAS:935868-50-1 Probechem Biochemicals

Chemical Structure : MK-1832

MK-1832 (MK1832)

Catalog No.: PC-62815Not For Human Use, Lab Use Only.

MK-1832 is a potent, selective Kv1.5 inhibitor with IC50 of 86 nM, exhibits improved selectivity for IKur over IKs (>3000-fold) compares with MK-0448 (70-fold).

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Biological Activity

MK-1832 is a potent, selective Kv1.5 inhibitor with IC50 of 86 nM, exhibits improved selectivity for IKur over IKs (>3000-fold) compares with MK-0448 (70-fold).
MK-1832 also exhibits an improved preclinical pharmacokinetic profile.
MK-1832 is a P-gp substrate and exhibits limited CNS exposure in vivo.

Physicochemical Properties

M.Wt	422.309
Formula	C23H17Cl2N3O
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-1-(2-(3,5-dichlorophenyl)pyridin-3-yl)-2,2-di(pyridin-3-yl)ethan-1-ol

References

1. Wolkenberg SE, et al. Bioorg Med Chem Lett. 2017 Feb 15;27(4):1062-1069.

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MK-1832 (MK1832)

Biological Activity

Physicochemical Properties

References

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