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Chemical Structure : MK-1903
Catalog No.: PC-21427Not For Human Use, Lab Use Only.
MK-1903 is potent and selective agonist of GPR109a with EC50 of 12.9 nM, Emax 102%.
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MK-1903 is potent and selective agonist of GPR109a with EC50 of 12.9 nM, Emax 102%.
MK-1903 exhibits no inhibition or binding against a standard panel of GPCRs and ion channels (PanLabs).
MK-1903 is more potent than niacin in the cell based assays.
MK-1903 induces robust decrease in plasma free fatty acids and produces the expected flush response in vivo.
| M.Wt | 164.16 | |
| Formula | C8H8N2O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Boatman PD, et al. J Med Chem. 2012 Apr 26;55(8):3644-66.
2. Brett Lauring, et al. Sci Transl Med. 2012 Aug 22;4(148):148ra115.
3. Viatchenko-Karpinski V, et al. Glia. 2022 Apr;70(4):634-649.
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