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Chemical Structure : MK-1925
Catalog No.: PC-61588Not For Human Use, Lab Use Only.
MK-1925 is a selective, orally active, brain-penetrant opioid receptor-like 1 (ORL1.
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MK-1925 is a selective, orally active, brain-penetrant opioid receptor-like 1 (ORL1, NOP receptor) antagonist with binding IC50 of 8.2 nM.
MK-1925 shows good selectivity over other opioid receptors and the hERG channel.
MK-1925 exhibits in vivo antagonist activity against the reduction in locomotor activity induced by ORL1 agonist in mice.
| M.Wt | 362.4 | |
| Formula | C19H21F3N4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Kobayashi K, et al. Bioorg Med Chem Lett. 2009 Aug 15;19(16):4729-32.
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