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Chemical Structure : MK-212
CAS No.: 61655-58-1
Catalog No.: PC-60817Not For Human Use, Lab Use Only.
MK-212 is a potent, selective 5-HT2C receptor agonist with IC50 of 20 nM in HEK293 cells-exppressed 5-HT2C, shows weakly activity for 5-HT2A.
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MK-212 is a potent, selective 5-HT2C receptor agonist with IC50 of 20 nM in HEK293 cells-exppressed 5-HT2C, shows weakly activity for 5-HT2A.
MK-212 stimulates phosphoinositide hydrolysis in cerebral cortex, antagonizes the analgesia induced by either morphine or THIP in vivo.
| M.Wt | 235.12 | |
| Formula | C8H11ClN4.HCl | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
6-Chloro-2-(1-piperazinyl)pyrazine hydrochloride |
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1. Conn PJ, et al. J Pharmacol Exp Ther. 1987 Aug;242(2):552-7.
2. Hemrick-Luecke SK, et al. Eur J Pharmacol. 1996 Sep 12;311(2-3):207-11.
3. Jensen AA, et al. J Med Chem. 2013 Feb 14;56(3):1211-27.
4. Murray TF, et al. Eur J Pharmacol. 1983 Jun 3;90(2-3):179-84.
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