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MK-212

Chemical Structure : MK-212

CAS No.: 61655-58-1

MK-212 (MK 212, MK212)

Catalog No.: PC-60817Not For Human Use, Lab Use Only.

MK-212 is a potent, selective 5-HT2C receptor agonist with IC50 of 20 nM in HEK293 cells-exppressed 5-HT2C, shows weakly activity for 5-HT2A.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

MK-212 is a potent, selective 5-HT2C receptor agonist with IC50 of 20 nM in HEK293 cells-exppressed 5-HT2C, shows weakly activity for 5-HT2A.
MK-212 stimulates phosphoinositide hydrolysis in cerebral cortex, antagonizes the analgesia induced by either morphine or THIP in vivo.

Physicochemical Properties

M.Wt 235.12
Formula C8H11ClN4.HCl
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

6-Chloro-2-(1-piperazinyl)pyrazine hydrochloride

References

1. Conn PJ, et al. J Pharmacol Exp Ther. 1987 Aug;242(2):552-7.

2. Hemrick-Luecke SK, et al. Eur J Pharmacol. 1996 Sep 12;311(2-3):207-11.

3. Jensen AA, et al. J Med Chem. 2013 Feb 14;56(3):1211-27.

4. Murray TF, et al. Eur J Pharmacol. 1983 Jun 3;90(2-3):179-84.

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