 
                Chemical Structure : MK-212
CAS No.: 61655-58-1
Catalog No.: PC-60817Not For Human Use, Lab Use Only.
MK-212 is a potent, selective 5-HT2C receptor agonist with IC50 of 20 nM in HEK293 cells-exppressed 5-HT2C, shows weakly activity for 5-HT2A.
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	MK-212 is a potent, selective 5-HT2C receptor agonist with IC50 of 20 nM in HEK293 cells-exppressed 5-HT2C, shows weakly activity for 5-HT2A.
	MK-212 stimulates phosphoinositide hydrolysis in cerebral cortex, antagonizes the analgesia induced by either morphine or THIP in vivo.
| M.Wt | 235.12 | |
| Formula | C8H11ClN4.HCl | |
| Appearance | Solid | |
| Storage | 
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| Solubility | 10 mM in DMSO | |
| Chemical Name/SMILES | 6-Chloro-2-(1-piperazinyl)pyrazine hydrochloride | |
1. Conn PJ, et al. J Pharmacol Exp Ther. 1987 Aug;242(2):552-7.
2. Hemrick-Luecke SK, et al. Eur J Pharmacol. 1996 Sep 12;311(2-3):207-11.
3. Jensen AA, et al. J Med Chem. 2013 Feb 14;56(3):1211-27.
4. Murray TF, et al. Eur J Pharmacol. 1983 Jun 3;90(2-3):179-84.

 
                 
                 
                 
                 
                 
                 
                 
                 
            
            
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