Catalog No.: PC-20434Not For Human Use, Lab Use Only.
MK-2305 (MK2305) is a potent and selective partial GPR40 (FFAR1) agonist with EC50 of 6 nM (rat GPR40), stimulates glucose stimulated insulin secretion (GSIS).
MK-2305 (MK2305) is a potent and selective partial GPR40 (FFAR1) agonist with EC50 of 6 nM (rat GPR40), stimulates glucose stimulated insulin secretion (GSIS).
MK-2305 binds to the same site as other GPR40 partial agonists such as AMG837 (Cat. PC-43813) and TAK-875 (Cat. PC-42610).
MK-2305 displays >2,000-fold selectivity over GPR120 (FFA4), GPR41 (FFA3), GPR43 (FFA2), PPARα, PPARδ, PPARγ.
MK-2305 acutely improved glucose tolerance and GSIS, significantly decreased AUC at doses between 10-0.3 mg/kg (by 54% to 18%, respectively).
MK-2305 (30 mg/kg) lowerd fasting and fed glucose following chronic administration.
