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Chemical Structure : MK-2305
Catalog No.: PC-20434Not For Human Use, Lab Use Only.
MK-2305 (MK2305) is a potent and selective partial GPR40 (FFAR1) agonist with EC50 of 6 nM (rat GPR40), stimulates glucose stimulated insulin secretion (GSIS).
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MK-2305 (MK2305) is a potent and selective partial GPR40 (FFAR1) agonist with EC50 of 6 nM (rat GPR40), stimulates glucose stimulated insulin secretion (GSIS).
MK-2305 binds to the same site as other GPR40 partial agonists such as AMG837 (Cat. PC-43813) and TAK-875 (Cat. PC-42610).
MK-2305 displays >2,000-fold selectivity over GPR120 (FFA4), GPR41 (FFA3), GPR43 (FFA2), PPARα, PPARδ, PPARγ.
MK-2305 acutely improved glucose tolerance and GSIS, significantly decreased AUC at doses between 10-0.3 mg/kg (by 54% to 18%, respectively).
MK-2305 (30 mg/kg) lowerd fasting and fed glucose following chronic administration.
| M.Wt | 443.82 | |
| Formula | C19H13ClF3NO4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Miller C, et al. PLoS One. 2017 May 23;12(5):e0176182.
2. Hauge M, et al. Mol Metab. 2015;4: 3–14. 10.1016/j.molmet.2014.10.002
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