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MK-2894

Chemical Structure : MK-2894

CAS No.: 1006036-87-8

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MK-2894 (MK 2894, MK2894)

Catalog No.: PC-42572Not For Human Use, Lab Use Only.

MK-2894 (MK2894) is a highly potent, selective, second generation prostaglandin E2 subtype 4 receptor (EP4) antagonist with Ki of 0.56 nM.

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5 mg $138 In stock
10 mg $218 In stock
25 mg $368 In stock
50 mg $558 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

MK-2894 (MK2894) is a highly potent, selective, second generation prostaglandin E2 subtype 4 receptor (EP4) antagonist with Ki of 0.56 nM.
MK-2894 displays >10,000-fold selectivity over EP2 receptors.
MK-2894 exhibits favorable pharmacokinetic profile and potent anti-inflammatory activity in animal models of pain/inflammation.

Physicochemical Properties

M.Wt 473.5073
Formula C25H22F3NO3S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Benzoic acid, 4-[1-[[[2,5-dimethyl-4-[[4-(trifluoromethyl)phenyl]methyl]-3-thienyl]carbonyl]amino]cyclopropyl]-

References

1. Blouin M, et al. J Med Chem. 2010 Mar 11;53(5):2227-38.

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