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MK-3281

Chemical Structure : MK-3281

CAS No.: 886041-60-7

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MK-3281 (MK3281)

Catalog No.: PC-63573Not For Human Use, Lab Use Only.

MK-3281 is a potent and orally bioavailable inhibitor of HCV NS5B polymerase with IC50 of 6 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    MK-3281 is a potent and orally bioavailable inhibitor of HCV NS5B polymerase with IC50 of 6 nM.
    MK-3281 is an equally potent inhibitor of gt 1a (EC50=28 nM), 1b BK (EC50=9 nM), and 3a (EC50=37 nM) replicons, shows 2 orders of magnitude less active on 2a (EC50=2018 nM) and 2b (EC50=1833 nM) replicons.
    MK-3281 demonstrates consistent decrease in viremia in vivo using the chimeric mouse model of HCV infection.

    Physicochemical Properties

    M.Wt 475.633
    Formula C29H37N3O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (7R)-14-Cyclohexyl-7-{[2-(dimethylamino)ethyl](methyl)amino}-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylic acid

    References

    1. Narjes F, et al. J Med Chem. 2011 Jan 13;54(1):289-301.

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