MK-3577 | GCGR antagonist | Probechem Biochemicals

Chemical Structure : MK-3577

MK-3577 (MK 3577, MK3577)

Catalog No.: PC-70055Not For Human Use, Lab Use Only.

MK-3577 is a potent, oral active glucagon receptor antagonist blocking the glucagon effect for the treatment of T2DM.

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Biological Activity

MK-3577 is a potent, oral active glucagon receptor antagonist blocking the glucagon effect for the treatment of T2DM.
MK-3577 inhibits glucagon-mediated cAMP increases in CHO cells expressing the human glucagon receptor with IC50 of 8.3 nM.

Physicochemical Properties

M.Wt	521.03
Formula	C30H30ClFN2O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(4-((1R,2S)-1-(4-chlorophenyl)-1-(7-fluoro-5-methyl-1H-indol-3-yl)pentan-2-yl)benzamido)propanoic acid

References

1. Peng JZ, et al. AAPS J. 2014 Nov;16(6):1259-70.

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MK-3577 (MK 3577, MK3577)

Biological Activity

Physicochemical Properties

References

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