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Chemical Structure : MK-4074
CAS No.: 1039758-22-9
Catalog No.: PC-61204Not For Human Use, Lab Use Only.
MK-4074 is a potent, liver-specific, orally active inhibitor of acetyl-CoA carboxylase ACC1 and ACC2 with IC50 of ~3 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $188 | In stock | |
| 10 mg | $298 | In stock | |
| 25 mg | Get quote | ||
| 100 mg | Get quote |
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MK-4074 is a potent, liver-specific, orally active inhibitor of acetyl-CoA carboxylase ACC1 and ACC2 with IC50 of ~3 nM.
MK-4074 lowers lipogenesis, increases ketones and reduces liver triglycerides, increases plasma triglycerides in mice.
MK-4074 significantly decreases de novo lipogenesis (DNL) in a dose-dependent manner with ID50 of 0.9 mg/kg in models of obesity, type 2 diabetes and fatty liver.
| M.Wt | 565.626 | |
| Formula | C33H31N3O6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
5-(1'-(1-cyclopropyl-4-methoxy-3-methyl-1H-indole-6-carbonyl)-4-oxospiro[chromane-2,4'-piperidin]-6-yl)nicotinic acid |
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1. Kim CW, et al. Cell Metab. 2017 Aug 1;26(2):394-406.e6.
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