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MK-4074 sodium salt

Chemical Structure : MK-4074 sodium salt

CAS No.: 1039758-18-3

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MK-4074 sodium salt

Catalog No.: PC-61206Not For Human Use, Lab Use Only.

MK-4074 is a potent, liver-specific, orally active inhibitor of acetyl-CoA carboxylase ACC1 and ACC2 with IC50 of ~3 nM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

MK-4074 is a potent, liver-specific, orally active inhibitor of acetyl-CoA carboxylase ACC1 and ACC2 with IC50 of ~3 nM; lowers lipogenesis, increases ketones and reduces liver triglycerides, increases plasma triglycerides in mice; significantly decreases de novo lipogenesis (DNL) in a dose-dependent manner with ID50 of 0.9 mg/kg in models of obesity, type 2 diabetes and fatty liver.

Steatohepatitis

Phase 1 Clinical

Physicochemical Properties

M.Wt 587.608
Formula C33H30N3NaO6
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

5-(1'-(1-cyclopropyl-4-methoxy-3-methyl-1H-indole-6-carbonyl)-4-oxospiro[chromane-2,4'-piperidin]-6-yl)nicotinic acid, sodium salt

References

1. Kim CW, et al. Cell Metab. 2017 Aug 1;26(2):394-406.e6.

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