Catalog No.: PC-61088Not For Human Use, Lab Use Only.
MK-4256 is a potent, selective, orally active somatostatin receptor SSTR3 antagonist with binding Ki of 0.66 nM, >500-fold selectivity over SSTR1/2/4/5.
MK-4256 is a potent, selective, orally active somatostatin receptor SSTR3 antagonist with binding Ki of 0.66 nM, >500-fold selectivity over SSTR1/2/4/5.
MK-4256 reduces glucose excursion in a dose-dependent fashion with maximal efficacy achieved at doses as low as 0.03 mg/kg po, with minimal hypoglycemia risk.
Preclinical tirals of MK-4256 are discontinued due to dose-dependent QTc in conscious cardiovascular (CV) dog model.
