MK-5661 (MK5661) | Nav1.8 inhibitor | Probechem Biochemicals

Chemical Structure : MK-5661

Catalog No.: PC-26880Not For Human Use, Lab Use Only.

MK-5661 (MK5661) is a potent, selective, and orally bioavailable NaV1.8 inhibitor with EC50 of 4.3 nM.

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Biological Activity

MK-5661 (MK5661) is a potent, selective, and orally bioavailable NaV1.8 inhibitor with EC50 of 4.3 nM.

M.Wt	479.43
Formula	C18H18F5N5O3S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-2-(4,4-difluoro-3-methylpiperidin-1-yl)-N-(2-sulfamoylpyridin-4-yl)-5-(trifluoromethyl)nicotinamide

1. Bungard CJ, et al. ACS Med Chem Lett. 2026 Apr 24;17(5):1189-1194.