Catalog No.: PC-45853Not For Human Use, Lab Use Only.
Quiflapon (MK-591, MK-0591, L-686708) sodium is a potent, orally active leukotriene biosynthesis inhibitor that acts by inhibiting 5-lipoxygenase activating protein (FLAP) with IC50 of 1.6 nM in a FLAP binding assay.
Quiflapon (MK-591, MK-0591, L-686708) sodium is a potent, orally active leukotriene biosynthesis inhibitor that acts by inhibiting 5-lipoxygenase activating protein (FLAP) with IC50 of 1.6 nM in a FLAP binding assay.
Quiflapon (MK-591) inhibits leukotriene (LT) biosynthesis in intact human and elicited rat PMNLs with IC50 of 3.1 nM and 6.1 nM, respectively.
Quiflapon (MK-591) inhibits the systemic generation of peptidoleukotrienes as measured by urinary LTE4 excretion in dogs (ED50=1 mg/kg).
Physicochemical Properties
M.Wt
609.1531
Formula
C34H34ClN2NaO3S
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
1H-Indole-2-propanoic acid, 1-[(4-chlorophenyl)methyl]-3-[(1,1-dimethylethyl)thio]-α,α-dimethyl-5-(2-quinolinylmethoxy)-, sodium salt (1:1)
References
1. Brideau C, et al. Can J Physiol Pharmacol. 1992 Jun;70(6):799-807.
2. Ménard L, et al. Can J Physiol Pharmacol. 1992 Jun;70(6):808-13.
