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Chemical Structure : MK-591
CAS No.: 147030-01-1
Catalog No.: PC-45853Not For Human Use, Lab Use Only.
Quiflapon (MK-591, MK-0591, L-686708) sodium is a potent, orally active leukotriene biosynthesis inhibitor that acts by inhibiting 5-lipoxygenase activating protein (FLAP) with IC50 of 1.6 nM in a FLAP binding assay.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $118 | In stock | |
| 10 mg | $178 | In stock | |
| 25 mg | $298 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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Quiflapon (MK-591, MK-0591, L-686708) sodium is a potent, orally active leukotriene biosynthesis inhibitor that acts by inhibiting 5-lipoxygenase activating protein (FLAP) with IC50 of 1.6 nM in a FLAP binding assay.
Quiflapon (MK-591) inhibits leukotriene (LT) biosynthesis in intact human and elicited rat PMNLs with IC50 of 3.1 nM and 6.1 nM, respectively.
Quiflapon (MK-591) inhibits the systemic generation of peptidoleukotrienes as measured by urinary LTE4 excretion in dogs (ED50=1 mg/kg).
| M.Wt | 609.1531 | |
| Formula | C34H34ClN2NaO3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1H-Indole-2-propanoic acid, 1-[(4-chlorophenyl)methyl]-3-[(1,1-dimethylethyl)thio]-α,α-dimethyl-5-(2-quinolinylmethoxy)-, sodium salt (1:1) |
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1. Brideau C, et al. Can J Physiol Pharmacol. 1992 Jun;70(6):799-807.
2. Ménard L, et al. Can J Physiol Pharmacol. 1992 Jun;70(6):808-13.
3. Tagari P, et al. J Pharmacol Exp Ther. 1993 Apr;265(1):416-25.
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