Catalog No.: PC-63367Not For Human Use, Lab Use Only.
MK-6169 is a potent, pan-genotype HCV NS5A inhibitor with replicon EC90 of 1-33 nM, retains potency against common resistance-associated substitutions in the major genotypes.
MK-6169 is a potent, pan-genotype HCV NS5A inhibitor with replicon EC90 of 1-33 nM, retains potency against common resistance-associated substitutions in the major genotypes.
MK-6169 shows <10X shift on a majority of the genotypes and mutants tested, other than several mutants, such as GT3a Y93H and GT3a L31V.
MK-6169 also show good potency on prototypical GT1a NS3 RASs such as GT1a R155K and GT1a V36M+R155K double substitution, as well as prototypical GT1b NS3 RASs such as GT1b A156T and GT1b D168Y.
MK-6169 exhibits good pharmacokinetics in both rat and dog.
