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Chemical Structure : MK-6892
CAS No.: 917910-45-3
Catalog No.: PC-42694Not For Human Use, Lab Use Only.
MK-6892 is a potent and selective high affinity niacin receptor (GPR109A) full agonist with Ki of 4.0 nM, EC50 of 16 nM in GTPγS assay.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $258 | In stock | |
| 10 mg | $398 | In stock | |
| 25 mg | $558 | In stock | |
| 100 mg | Get quote |
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MK-6892 is a potent and selective high affinity niacin receptor (GPR109A) full agonist with Ki of 4.0 nM, EC50 of 16 nM in GTPγS assay.
MK-6892 has no activity on closely related GPCRs GPR109B and GPR81.
MK-6892 displays good PK across species, remarkably clean off-target profiles, and superior therapeutic window over niacin regarding the FFA reduction versus vasodilation in rats and dogs.
| M.Wt | 386.4018 | |
| Formula | C19H22N4O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1-Cyclohexene-1-carboxylic acid, 2-[[3-[3-(5-hydroxy-2-pyridinyl)-1,2,4-oxadiazol-5-yl]-2,2-dimethyl-1-oxopropyl]amino]- |
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1. Shen HC, et al. J Med Chem. 2010 Mar 25;53(6):2666-70.
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