MK-6892 is a potent and selective high affinity niacin receptor (GPR109A) full agonist with Ki of 4.0 nM, EC50 of 16 nM in GTPγS assay.
MK-6892 has no activity on closely related GPCRs GPR109B and GPR81.
MK-6892 displays good PK across species, remarkably clean off-target profiles, and superior therapeutic window over niacin regarding the FFA reduction versus vasodilation in rats and dogs.
