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Chemical Structure : MK-7145
Catalog No.: PC-60460Not For Human Use, Lab Use Only.
MK-7145 is a potent, selective, and oral renal outer medullary potassium channel (ROMK, Kir1.1) inhibitor with IC50 of 68 nM.
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MK-7145 is a potent, selective, and oral renal outer medullary potassium channel (ROMK, Kir1.1) inhibitor with IC50 of 68 nM.
MK-7145 shows no significant activity on Kir family of channels and cardiac ion channels such as Cav1.2 and Nav1.5 (IC50>30 uM).
MK-7145 evokes remarkable diuresis and natriuresis in the acute rat diuresis model at 0.3 mg/kg, causes dose-dependent lowering of blood pressure in a subchronic SHR model.
| M.Wt | 466.534 | |
| Formula | C26H30N2O6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Hampton C, et al. J Pharmacol Exp Ther. 2016 Oct;359(1):194-206.
2. Tang H, et al. ACS Med Chem Lett. 2016 May 12;7(7):697-701.
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