MK-8141 (ACT-077825) | Renin inhibitor

Chemical Structure : MK-8141

Catalog No.: PC-62600Not For Human Use, Lab Use Only.

MK-8141 (ACT-077825) is a potent, selective, direct Renin inhibitor for the treatment of cardiovascular disorders.

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Biological Activity

MK-8141 (ACT-077825) is a potent, selective, direct Renin inhibitor for the treatment of cardiovascular disorders.

M.Wt	620.615
Formula	C35H39Cl2N3O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(1S,5R)-N-cyclopropyl-7-(4-(2-(2,6-dichloro-4-methylphenoxy)ethoxy)phenyl)-N-(2,3-dimethylbenzyl)-3,9-diazabicyclo[3.3.1]non-6-ene-6-carboxamide

1. Dingemanse J, et al. Pharmacology. 2014;94(3-4):135-42. doi: 10.1159/000362822.

2. Nicolas LB, et al. J Cardiovasc Pharmacol. 2013 Jan;61(1):42-50.

3. Jones-Burton C, et al. J Am Soc Hypertens. 2010 Sep-Oct;4(5):219-26.