Chemical Structure : MK-8153
CAS No.:
1548286-45-8
MK-8153
(MK8153)
Catalog No.: PC-24561Not For Human Use, Lab Use Only.
MK-8153 (MK8153) is a potent, selective inhibitor of renal outer medullary potassium channel (ROMK, Kir1.1) with IC50 of 5 nM, 3,400-fold over hERG.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
MK-8153 (MK8153) is a potent, selective inhibitor of renal outer medullary potassium channel (ROMK, Kir1.1) with IC50 of 5 nM, 3,400-fold over hERG.
MK-8153 inhibits current through rat ROMK, rKir1.1/HEK293 cells in electrophysiological recordings with an IC50 value of 2.5 nM.
MK-8153 also shows no activity against related inward rectifying potassium channels (Kir2.1, Kir4.1, and Kir7.1 IC50s > 100 μM) as well as the cardiac channels Nav 1.5 and Cav 1.2 (>30 μM).
MK-8153 (1-3 mg/kg/day) caused a dose-dependent decrease in systolic blood pressure in aged SHRs.
Physicochemical Properties
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M.Wt
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440.50
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Formula
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C24H28N2O6
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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2,8-Diazaspiro[4.5]decan-1-one, 2-(2,5-dihydro-4-methyl-5-oxo-3-furanyl)-8-[(2R)-2-(1,3-dihydro-4-methyl-1-oxo-5-isobenzofuranyl)-2-hydroxyethyl]-
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References
1. Jiang J, et al. J Med Chem. 2021 Jun 10;64(11):7691-7701.
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