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Chemical Structure : MK-8282
Catalog No.: PC-63460Not For Human Use, Lab Use Only.
MK-8282 is a potent, selective, oral GPR119 agonist with EC50 of 10 and 58 nM for hGPR119 and mGPR119, respectively.
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MK-8282 is a potent, selective, oral GPR119 agonist with EC50 of 10 and 58 nM for hGPR119 and mGPR119, respectively.
MK-8282 shows >150 fold selectivity over other receptors (Eurofin panlabs assay), transporters and ion channels.
MK-8282 exhibits improved glucose tolerance in multiple animal models and has excellent off-target profile.
| M.Wt | 503.915 | |
| Formula | C23H23ClFN5O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Santhosh F. Neelamkavil, et al. ACS Med. Chem. Lett. 2018. DOI: 10.1021/acsmedchemlett.8b00073.
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