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MK-8325

Chemical Structure : MK-8325

CAS No.: 1334312-52-5

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MK-8325 (MK8325)

Catalog No.: PC-63303Not For Human Use, Lab Use Only.

MK-8325 is a potent, selective pan-genotype HCV NS5A inhibitor with IC50 of 15, 1 and 3 pM for GT1a, GT1b and GT2a, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    MK-8325 is a potent, selective pan-genotype HCV NS5A inhibitor with IC50 of 15, 1 and 3 pM for GT1a, GT1b and GT2a, respectively.
    MK-8325 also demonstrates potencies comparable to MK-4882 against a panel of mutants in both the GT1a and GT1b backgrounds (GT1a M28V IC50=0.1 nM)。
    MK-8325 demonstrates no cell toxicity with a CC50 >25 uM against Huh-7 replicon cells.

    Physicochemical Properties

    M.Wt 843.021
    Formula C43H52F2N8O6Si
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    methyl ((S)-1-((R)-5-(7-(4-(2-((S)-4,4-difluoro-1-((methoxycarbonyl)-L-valyl)pyrrolidin-2-yl)-1H-imidazol-5-yl)phenyl)-1H-naphtho[1,2-d]imidazol-2-yl)-3,3-dimethyl-1,3-azasilolidin-1-yl)-3-methyl-1-oxobutan-2-yl)carbamate

    References

    1. Nair AG, et al. Bioorg Med Chem Lett. 2018 Mar 20. pii: S0960-894X(18)30242-7.

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