MK-8325 dihydrochloride is a potent, selective pan-genotype HCV NS5A inhibitor with IC50 of 15, 1 and 3 pM for GT1a, GT1b and GT2a, respectively.
MK-8325 also demonstrates potencies comparable to MK-4882 against a panel of mutants in both the GT1a and GT1b backgrounds (GT1a M28V IC50=0.1 nM).
MK-8325 demonstrates no cell toxicity with a CC50 >25 uM against Huh-7 replicon cells.
