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MK-8591

Chemical Structure : MK-8591

CAS No.: 865363-93-5

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MK-8591 (Islatravir, MK8591, EFdA)

Catalog No.: PC-61817Not For Human Use, Lab Use Only.

MK-8591 (Islatravir, MK8591, EFdA) is a nucleoside analog that exhibits remarkable potency against wild-type and drug-resistant HIVs, inhibits HIV-1 reverse transcriptase with multiple mechanisms.

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5 mg $198 In stock
10 mg $288 In stock
25 mg $458 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

MK-8591 (Islatravir, MK8591, EFdA) is a nucleoside analog that exhibits remarkable potency against wild-type and drug-resistant HIVs, inhibits HIV-1 reverse transcriptase with multiple mechanisms.
MK-8591 also retains potent activity against multinucleoside-resistant HIV-2 mutants (EC50<11 nM).

Physicochemical Properties

M.Wt 293.25
Formula C12H12FN5O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(2R,3S,5R)-5-(6-amino-2-fluoro-9H-purin-9-yl)-2-ethynyl-2-(hydroxymethyl)tetrahydrofuran-3-ol

References

1. Wu VH, et al. Antimicrob Agents Chemother. 2017 Jul 25;61(8). pii: e00744-17.

2. Salie ZL, et al. Proc Natl Acad Sci U S A. 2016 Aug 16;113(33):9274-9.

3. Michailidis E, et al. J Biol Chem. 2014 Aug 29;289(35):24533-48.

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