Chemical Structure : MK-8825
CAS No.:
1380887-60-4
MK-8825
(MK8825)
Catalog No. : PC-62994Not For Human Use, Lab Use Only.
MK-8825 is a highly potent, selective, orally bioavailable CGRP receptor antagonist with Ki of 17 nM for rat CGRP.
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Purity & Documentation Purity:
>98% (HPLC) Select Batch: PC-6299401
Biological Activity
MK-8825 is a highly potent, selective, orally bioavailable CGRP receptor antagonist with Ki of 17 nM for rat CGRP.
Physicochemical Properties
M.Wt
572.617
Formula
C31H30F2N6O3
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
2-[(8R)-8-(3,5-difluorophenyl)-8-methyl-10-oxo-6,9-diazaspiro[4.5]dec-9-yl]-N-[(6S)-2'-oxo-1',2',5,7-tetrahydrospiro[cyclopenta[b]pyridine-6,3'-pyrrolo[2,3-b]pyridin]-3-yl]acetamide
References
1. Bell IM, et al. Bioorg Med Chem Lett. 2012 Jun 15;22(12):3941-5.
2. Michot B, et al. Eur J Pain. 2015 Feb;19(2):281-90.
3. Romero-Reyes M, et al. Exp Neurol. 2015 Sep;271:95-103.
4. Feistel S, et al. J Headache Pain. 2013 Nov 20;14:93.
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