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Chemical Structure : MK-886
CAS No.: 118414-82-7
Catalog No.: PC-20006Not For Human Use, Lab Use Only.
MK-886 (L-663,536) is a potent, selective and orally active inhibitor of 5-lipoxygenase-activating protein (FLAP) with IC50 of 30 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $98 | In stock | |
| 25 mg | $168 | In stock | |
| 50 mg | $268 | In stock | |
| 100 mg | $458 | In stock | |
| 250 mg | Get quote |
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MK-886 (L-663,536) is a potent, selective and orally active inhibitor of 5-lipoxygenase-activating protein (FLAP) with IC50 of 30 nM.
MK-886 inhibits leukotriene biosynthesis in human polymorphonuclear leukocytes with IC50 of 3 nM.
MK-886 (10 mg/kg, i.v., 15 min before antigen challenge) suppressed the antigen-induced cysteinyl LT production by greater than 92% in sensitized guinea pigs.
| M.Wt | 472.08 | |
| Formula | C27H34ClNO2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1-[(4-chlorophenyl)methyl]-3-[(1,1-dimethylethyl)thio]-alpha,alpha-dimethyl-5-(1-methylethyl)-1H-indole-2-propanoic acid |
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1. Guhlmann A, et al. J Exp Med. 1989 Dec 1;170(6):1905-18.
2. Gillard J, et al. Can J Physiol Pharmacol. 1989 May;67(5):456-64.
3. Dixon RA, et al. Nature. 1990 Jan 18;343(6255):282-4.
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