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MK-886

Chemical Structure : MK-886

CAS No.: 118414-82-7

MK-886 (L-663,536)

Catalog No.: PC-20006Not For Human Use, Lab Use Only.

MK-886 (L-663,536) is a potent, selective and orally active inhibitor of 5-lipoxygenase-activating protein (FLAP) with IC50 of 30 nM.

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50 mg $348 In stock
100 mg $558 In stock
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Biological Activity

MK-886 (L-663,536) is a potent, selective and orally active inhibitor of 5-lipoxygenase-activating protein (FLAP) with IC50 of 30 nM.
MK-886 inhibits leukotriene biosynthesis in human polymorphonuclear leukocytes with IC50 of 3 nM.
MK-886 (10 mg/kg, i.v., 15 min before antigen challenge) suppressed the antigen-induced cysteinyl LT production by greater than 92% in sensitized guinea pigs.

Physicochemical Properties

M.Wt 472.08
Formula C27H34ClNO2S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

1-[(4-chlorophenyl)methyl]-3-[(1,1-dimethylethyl)thio]-alpha,alpha-dimethyl-5-(1-methylethyl)-1H-indole-2-propanoic acid

References

1. Guhlmann A, et al. J Exp Med. 1989 Dec 1;170(6):1905-18.

2. Gillard J, et al. Can J Physiol Pharmacol. 1989 May;67(5):456-64.

3. Dixon RA, et al. Nature. 1990 Jan 18;343(6255):282-4.

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