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MK-8876

Chemical Structure : MK-8876

CAS No.: 1426960-33-9

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MK-8876 (MK 8876, MK8876)

Catalog No.: PC-60429Not For Human Use, Lab Use Only.

MK-8876 is a broadly acting non-nucleoside inhibitor of HCV NS5B polymerase with IC50 of 3 nM and 2 nM for GT1b and GT2a, respectively..

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    MK-8876 is a broadly acting non-nucleoside inhibitor of HCV NS5B polymerase with IC50 of 3 nM and 2 nM for GT1b and GT2a, respectively.
    MK-8876 demonstrates a pan-genotypic potency profile and maintains potency against clinically relevant mutants.
    MK-8876 has moderate bioavailability in rats and dogs, but shows low plasma clearance characteristics consistent with once-daily dosing.

    Physicochemical Properties

    M.Wt 614.62
    Formula C32H24F2N4O5S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-(4-Fluorophenyl)-5-(11-fluoro-6H-pyrido[2',3':5,6][1,3]oxazino[3,4-a]indol-2-yl)-N-methyl-6-[methyl(methylsulfonyl)amino]-3-benzofurancarboxamide

    References

    1. McComas CC, et al. ChemMedChem. 2017 Sep 7;12(17):1436-1448.

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