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Chemical Structure : MK2-IN-1 hydrochloride
CAS No.: 1314118-94-9
Catalog No.: PC-43244Not For Human Use, Lab Use Only.
MK2-IN-1 is a potent, selecitve, non-ATP competitive MAPKAPK2 (MK2) inhibitor with IC50 of 0.11 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $188 | In stock | |
| 10 mg | $328 | In stock | |
| 25 mg | Get quote | ||
| 100 mg | Get quote |
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MK2-IN-1 hydrochloride is a potent, selecitve, non-ATP competitive MAPKAPK2 (MK2) inhibitor with IC50 of 0.11 uM.
MK2-IN-1 shows excellent kinase selectivity against a broad panel of 150 protein kinases at 10 μM with only on exception of CK1γ3 >50 % inhibition.
MK2-IN-1 inhibits pro-inflammatory cytokine secretion from the human THP1 acute monocytic leukemia cell line, causing dose-dependent inhibition of LPS-stimulated TNFα and IL6 secretion.
MK2-IN-1 also dose dependently inhibits IL1β-stimulated MMP13 secretion from the SW1353 chondrosarcoma cell line and human primary chondrocyte cultures.
| M.Wt | 509.4269 | |
| Formula | C27H26Cl2N4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO |
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| Chemical Name/SMILES |
2-Furancarboxamide, 5-(4-chlorophenyl)-N-[4-(1-piperazinyl)phenyl]-N-(2-pyridinylmethyl)-, hydrochloride (1:1) |
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1. Rao AU, et al. Bioorg Med Chem Lett. 2012 Jan 15;22(2):1068-72.
2. Huang X, et al. Bioorg Med Chem Lett. 2012 Jan 1;22(1):65-70.
3. Huang X, et al. ACS Med Chem Lett. 2011 Jun 24;2(8):632-7.
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