MK2-IN-1 hydrochloride is a potent, selecitve, non-ATP competitive MAPKAPK2 (MK2) inhibitor with IC50 of 0.11 uM.
MK2-IN-1 shows excellent kinase selectivity against a broad panel of 150 protein kinases at 10 μM with only on exception of CK1γ3 >50 % inhibition.
MK2-IN-1 inhibits pro-inflammatory cytokine secretion from the human THP1 acute monocytic leukemia cell line, causing dose-dependent inhibition of LPS-stimulated TNFα and IL6 secretion.
MK2-IN-1 also dose dependently inhibits IL1β-stimulated MMP13 secretion from the SW1353 chondrosarcoma cell line and human primary chondrocyte cultures.
