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MK2-IN-28

Chemical Structure : MK2-IN-28

CAS No.: 1355617-50-3

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MK2-IN-28

Catalog No.: PC-70144Not For Human Use, Lab Use Only.

MK2-IN-28 is a potent and selective, non-ATP competitive, allosteric MAPKAPK2/3 (MK2/3) inhibitor with IC50 of 8 nM for MK2, hTNFα EC50 of 0.31 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    MK2-IN-28 is a potent and selective, non-ATP competitive, allosteric MAPKAPK2/3 (MK2/3) inhibitor with IC50 of 8 nM for MK2, hTNFα EC50 of 0.31 uM. MK2-IN-28 inhibits both MK2 and MK3, and has no or little effect on the other kinases.
    MK2-IN-28 ameliorates glucose homeostasis by suppressing excessive HGP and enhancing insulin signaling in obese mice.

    Physicochemical Properties

    M.Wt 569.665
    Formula C35H31N5O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    5-(4-cyanophenyl)-N-(2-(4-methoxypyridin-3-yl)benzyl)-N-(4-(piperazin-1-yl)phenyl)furan-2-carboxamide

    References

    1. Huang X, et al. Bioorg Med Chem Lett. 2012 Jan 1;22(1):65-70.

    2. Ozcan L, et al. Diabetes. 2015 Oct;64(10):3396-405.

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