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Chemical Structure : MK2 inhibitor III
CAS No.: 1186648-22-5
Catalog No.: PC-70147Not For Human Use, Lab Use Only.
MK2 inhibitor III (MK2-IN-3) is a potent, cell-permeable inhibitor of MAPKAPK2 (MK2) with IC50 of 8.5 nM.
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| 5 mg | $298 | In stock | |
| 10 mg | $488 | In stock | |
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MK2 inhibitor III (MK2-IN-3) is a potent, cell-permeable inhibitor of MAPKAPK2 (MK2) with IC50 of 8.5 nM.
MK2 inhibitor III (MK2-IN-3) less potently blocks MK3 and MK5 (IC50s=210 and 81 nM, respectively and is weak or inactive against several other kinases, including P38 MAPKs.
MK2 inhibitor III (MK2-IN-3) prevents LPS-induced synthesis of TNF-α in human monocyte-like U937 cells with IC50 of 4.4 uM.
| M.Wt | 358.4 | |
| Formula | C21H16N4O • H2O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-(2-(quinolin-3-yl)pyridin-4-yl)-1,5,6,7-tetrahydro-4H-pyrrolo[3,2-c]pyridin-4-one hydrate |
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1. Anderson DR, et al. J Med Chem. 2007 May 31;50(11):2647-54.
2. Gurgis F, et al. Cell Death Discov. 2015 Sep 7;1:15028.
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