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Chemical Structure : MKC-733
CAS No.: 194093-42-0
Catalog No.: PC-61221Not For Human Use, Lab Use Only.
MKC-733 (Pumosetrag, DDP 733) is a potent, selective, orally active 5-HT3 receptor agonist with high affinity for canine intestinal smooth muscle 5-HT3 receptors.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $158 | In stock | |
| 25 mg | $268 | In stock | |
| 50 mg | $488 | In stock | |
| 100 mg | Get quote |
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MKC-733 (Pumosetrag, DDP 733) is a potent, selective, orally active 5-HT3 receptor agonist with high affinity for canine intestinal smooth muscle 5-HT3 receptors.
MKC-733 dose dependently stimulates contraction and basal electrolyte secretion in the isolated guinea pig colon, effects that are antagonized by the selective 5-HT3 antagonist ondansetron,.
MKC-733 also accelerates gastric emptying in some animal models.
| M.Wt | 39.838 | |
| Formula | C15H18ClN3O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
Thieno[3,2-b]pyridine-6-carboxamide, N-(3R)-1-azabicyclo[2.2.2]oct-3-yl-4,7-dihydro-7-oxo-, monohydrochloride (9CI) |
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1. Coleman NS, et al. Aliment Pharmacol Ther. 2003 Nov 15;18(10):1039-48.
2. Fujita T, et al.
3. Chetty N, et al. Pharmacology. 2008;81(2):104-9.
4. Choung RS, et al. Neurogastroenterol Motil. 2014 Jan;26(1):13-20.
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