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ML-007

Chemical Structure : ML-007

CAS No.: 1314018-44-4

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ML-007 (ML007)

Catalog No.: PC-25834Not For Human Use, Lab Use Only.

ML-007 is a potent brain-penetrant agonist at both M1 and M4 muscarinic receptors with EC50 of 120 and 830  nM for huamn M1 and M4 receptors, 340 and 1600 nM for rat M1 and M4 receptors.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

ML-007 is a potent brain-penetrant agonist at both M1 and M4 muscarinic receptors with EC50 of 120 and 830  nM for huamn M1 and M4 receptors, 340 and 1600 nM for rat M1 and M4 receptors.
ML-007 has demonstrated compelling efficacy across a range of preclinical models of psychosis in schizophrenia including amphetamine-induced hyperlocomotion, PCP-induced hyperlocomotion, and conditioned avoidance response.
ML-007 is approximately ten-fold more potent than the comparator xanomeline.

Physicochemical Properties

M.Wt 165.20
Formula C8H11N3O
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

5-((1R,5R)-3-azabicyclo[3.1.0]hexan-1-yl)-3-methyl-1,2,4-oxadiazole

References

1. Chatterjee S, et al. Neuropsychopharmacology. 2025 Oct 4. doi: 10.1038/s41386-025-02256-3.

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