Catalog No.: PC-25834Not For Human Use, Lab Use Only.
Betovumeline (ML-007, MPL-0527) is a potent brain-penetrant agonist at both M1 and M4 muscarinic receptors with EC50 of 120 and 830 nM for huamn M1 and M4 receptors, 340 and 1600 nM for rat M1 and M4 receptors.
Betovumeline (ML-007, MPL-0527) is a potent brain-penetrant agonist at both M1 and M4 muscarinic receptors with EC50 of 120 and 830 nM for huamn M1 and M4 receptors, 340 and 1600 nM for rat M1 and M4 receptors.
ML-007 has demonstrated compelling efficacy across a range of preclinical models of psychosis in schizophrenia including amphetamine-induced hyperlocomotion, PCP-induced hyperlocomotion, and conditioned avoidance response.
ML-007 is approximately ten-fold more potent than the comparator xanomeline.
