Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : ML-109
CAS No.: 1186649-91-1
Catalog No.: PC-35977Not For Human Use, Lab Use Only.
ML-109 (ML109, CID-25246343) is the first selective and orally available small-molecule thyroid stimulating hormone receptor (TSHR) agonist with EC50 of 40 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $198 | In stock | |
| 10 mg | $298 | In stock | |
| 25 mg | $498 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
ML-109 (ML109, CID-25246343) is the first selective and orally available small-molecule thyroid stimulating hormone receptor (TSHR) agonist with EC50 of 40 nM.
ML109 is highly selective for human TSHR over other glycoprotein hormone receptors, such as LHCGR and FSHR (EC50>100 uM), and interacts with the receptor’s serpentine domain.
ML-109 increases mRNA levels for thyroglobulin, thyroperoxidase, sodium iodide symporter, and deiodinase type 2, as well as deiodinase type2 enzyme activity in primary cultures of human thyrocytes.
ML-109 stimulated thyroid function in mice.
| M.Wt | 523.589 | |
| Formula | C31H29N3O5 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
N-(4-(5-(3-benzyl-5-hydroxy-4-oxo-1,2,3,4-tetrahydroquinazolin-2-yl)-2-methoxybenzyloxy)-phenyl)acetamide |
|
1. Neumann S, et al. Proc Natl Acad Sci U S A. 2009 Jul 28;106(30):12471-6.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
