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ML-184

Chemical Structure : ML-184

CAS No.: 794572-10-4

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ML-184 (ML184)

Catalog No.: PC-70188Not For Human Use, Lab Use Only.

ML-184 (ML184) is a potent, selective GPR55 agonist with EC50 of 263 nM, >120-fold, 83-fold, and 57-fold selectivity against GPR35, CB1 and CB2.

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10 mg $388 In stock
25 mg $588 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

ML-184 (ML184) is a potent, selective GPR55 agonist with EC50 of 263 nM, >120-fold, 83-fold, and 57-fold selectivity against GPR35, CB1 and CB2.
ML-184 shows activity in activating the downstream responses of ERK phosphorylation and PKC β II translocation.

Physicochemical Properties

M.Wt 470.6
Formula C25H34N4O3S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3-[[4-(2,3-Dimethylphenyl)-1-piperazinyl]carbonyl]-N,N-dimethyl-4-(1-pyrrolidinyl)benzenesulfonamide

References

1. Heynen-Genel S, et al. Probe Reports from the NIH Molecular Libraries Program [Internet].

2. Lingerfelt MA, et al. Biochemistry. 2017 Jan 24;56(3):473-486.

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