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Chemical Structure : ML-T531
Catalog No.: PC-60835Not For Human Use, Lab Use Only.
ML-T531 (CFK332-B) is a potent, selective hERG potassium channel (Kv11.1) activator with EC50 of 3.13 uM.
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ML-T531 (CFK332-B) is a potent, selective hERG potassium channel (Kv11.1) activator with EC50 of 3.13 uM.
ML-T531 exhibits no potentiation for KCNQ1 and KCNE1, and no noticeable effects on other cardiac channels including Cav1.2, Kir2.1, Nav1.5, and Kv4.3.
ML-T531 significantly potentiates hERG steady-state currents and tail currents in CHO cells at 10 uM, enhances voltage-dependent potassium current amplitudes in the presence of an Iks-specific inhibitor chromanol 293B.
ML-T531 potentiates native potassium currents in iPSC-derived cardiomyocytes, shortens the APD90 of LQT1 cardiomyocytes with EC50 of 5.71 uM, normalizes the disease phenotype of cardiomycytes derived from a patient with LQT1.
| M.Wt | 332.359 | |
| Formula | C20H16N2O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Zhang H, et al. Proc Natl Acad Sci U S A. 2012 Jul 17;109(29):11866-71.
2. Yu Z, et al. Eur J Med Chem. 2015 Dec 1;106:50-9.
3. Yu Z, et al. Circ Arrhythm Electrophysiol. 2016 Apr;9(4):e003439.
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