Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : ML115
Catalog No.: PC-62732Not For Human Use, Lab Use Only.
ML115 is a novel "bone-seeking" bisphosphonate based MMP-2 specific inhibitor (BMMPI), spares the activity of other MMPs including MMP-9.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
ML115 is a novel "bone-seeking" bisphosphonate based MMP-2 specific inhibitor (BMMPI), spares the activity of other MMPs including MMP-9.
ML115 affects the viability of breast cancer cell lines and osteoclast precursors, but not osteoblasts in vitro, significantly reduces tumor growth and tumor-associated bone destruction in bone metastatic models (PyMT-R221A and 4T1).
ML115 also decreases multiple myeloma burden and protect against cancer-induced osteolysis, specifically inhibits in the multiple myeloma-bone microenvironment.
| M.Wt | 407.27 | |
| Formula | C13H15NO8P2S | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Tauro M, et al. Mol Cancer Ther. 2017 Mar;16(3):494-505.
2. Shay G, et al. Oncotarget. 2017 Jun 27;8(26):41827-41840.
3. Rubino MT, et al. ChemMedChem. 2011 Jul 4;6(7):1258-68.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
