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ML115

Chemical Structure : ML115

CAS No.: 1314124-91-8

ML115 (ML 115)

Catalog No.: PC-62732Not For Human Use, Lab Use Only.

ML115 is a novel bone-seeking, bisphosphonate based MMP-2 specific inhibitor (BMMPI), spares the activity of other MMPs including MMP-9.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    ML115 is a novel bone-seeking, bisphosphonate based MMP-2 specific inhibitor (BMMPI), spares the activity of other MMPs including MMP-9.
    ML115 affects the viability of breast cancer cell lines and osteoclast precursors, but not osteoblasts in vitro, significantly reduces tumor growth and tumor-associated bone destruction in bone metastatic models (PyMT-R221A and 4T1).
    ML115 also decreases multiple myeloma burden and protect against cancer-induced osteolysis, specifically inhibits in the multiple myeloma-bone microenvironment.

    Physicochemical Properties

    M.Wt 407.27
    Formula C13H15NO8P2S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    (([1,1'-biphenyl]-4-sulfonamido)methylene)bis(phosphonic acid)

    References

    1. Tauro M, et al. Mol Cancer Ther. 2017 Mar;16(3):494-505.

    2. Shay G, et al. Oncotarget. 2017 Jun 27;8(26):41827-41840.

    3. Rubino MT, et al. ChemMedChem. 2011 Jul 4;6(7):1258-68.

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