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Chemical Structure : ML133 hydrochloride
CAS No.: 1222781-70-5
Catalog No.: PC-62357Not For Human Use, Lab Use Only.
ML133 (CID781301) is a potent, selective K(ir)2.1 potassium channel with IC50 of 1.8 uM at pH 7.4 and 290 nM at pH 8.5, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $78 | In stock | |
| 25 mg | $118 | In stock | |
| 50 mg | $188 | In stock | |
| 100 mg | $288 | In stock | |
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ML133 (CID781301) hydrochlorideis a potent, selective K(ir)2.1 potassium channel with IC50 of 1.8 uM at pH 7.4 and 290 nM at pH 8.5, respectively.
ML133 exhibits little selectivity against other members of Kir2.x family channels, but displays excellent selectivity over K(ir)1.1, K(ir)4.1 and K(ir)7.1.
ML133 dramatically reduces Ca2+ influx through Ca2+-release-activated Ca2+ (CRAC) channels.
| M.Wt | 313.825 | |
| Formula | C19H20ClNO | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
N-[(4-Methoxyphenyl)methyl]-1-naphthalenemethanamine hydrochloride |
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1. Wang HR, et al. ACS Chem Biol. 2011 Aug 19;6(8):845-56.
2. Wu M, et al. Probe Reports from the NIH Molecular Libraries Program [Internet].
3. Ford NC, et al. Neuroscience. 2016 Dec 17;339:502-510.
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