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Chemical Structure : ML165
Catalog No.: PC-61134Not For Human Use, Lab Use Only.
ML165 (RUC-2) is a high-affinity, selective platelet integrin αIIbβ3 receptor antagonist with IC50 of 96 nM.
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ML165 (RUC-2) is a high-affinity, selective platelet integrin αIIbβ3 receptor antagonist with IC50 of 96 nM.
ML165 (RUC-2) specifically inhibits ligand binding by a novel mechanism, leading to loss of the MIDAS metal ion while producing only minor changes in the conformation of β3.
| M.Wt | 385.446 | |
| Formula | C17H19N7O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Zhu J, et al. Sci Transl Med. 2012 Mar 14;4(125):125ra32.
2. Jiang JK, et al. Bioorg Med Chem Lett. 2014 Feb 15;24(4):1148-53.
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