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ML165

Chemical Structure : ML165

CAS No.: 1355454-05-5

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ML165 (RUC-2, ML 165)

Catalog No.: PC-61134Not For Human Use, Lab Use Only.

ML165 (RUC-2) is a high-affinity, selective platelet integrin αIIbβ3 receptor antagonist with IC50 of 96 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    ML165 (RUC-2) is a high-affinity, selective platelet integrin αIIbβ3 receptor antagonist with IC50 of 96 nM.
    ML165 (RUC-2) specifically inhibits ligand binding by a novel mechanism, leading to loss of the MIDAS metal ion while producing only minor changes in the conformation of β3.

    Physicochemical Properties

    M.Wt 385.446
    Formula C17H19N7O2S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-amino-N-(3-(5-oxo-7-(piperazin-1-yl)-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-2-yl)phenyl)acetamide

    References

    1. Zhu J, et al. Sci Transl Med. 2012 Mar 14;4(125):125ra32.

    2. Jiang JK, et al. Bioorg Med Chem Lett. 2014 Feb 15;24(4):1148-53.

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