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Chemical Structure : ML193
CAS No.: 713121-80-3
Catalog No.: PC-35195Not For Human Use, Lab Use Only.
ML193 (CID 1261822) is a potent, selective GPR55 antagonist with IC50 of 221 nM, shows >27-, >145- and >145-fold selectivity for GPR55 over CB1, GPR35 and CB2, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $188 | In stock | |
| 25 mg | $288 | In stock | |
| 50 mg | $458 | In stock | |
| 100 mg | Get quote |
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ML193 (CID 1261822) is a potent, selective GPR55 antagonist with IC50 of 221 nM, shows >27-, >145- and >145-fold selectivity for GPR55 over CB1, GPR35 and CB2, respectively.
ML193 reduces neuronal differentiation in vitro, increases anxiety-like behaviors while causing locomotor impairment by i.c.v. injection at the doses of 0.1 and 1 μg/rat.
| M.Wt | 527.59 | |
| Formula | C28H25N5O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
N-[4-[[(3,4-Dimethyl-5-isoxazolyl)amino]sulfonyl]phenyl]-6,8-dimethyl-2-(2-pyridinyl)-4-quinolinecarboxamide |
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1. Kotsikorou E, et al. Biochemistry. 2013 Dec 31;52(52):9456-69.
2. Munawar N, et al. Front Pharmacol. 2017 Mar 20;8:136.
3. Drzazga A, et al. Biochem Biophys Res Commun. 2017 Jul 22;489(2):242-247.
4. Hill JD, et al. Br J Pharmacol. 2018 Jun 11. doi: 10.1111/bph.14387.
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