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ML193

Chemical Structure : ML193

CAS No.: 713121-80-3

ML193 (ML 193;ML-193;CID 1261822)

Catalog No.: PC-35195Not For Human Use, Lab Use Only.

ML193 (CID 1261822) is a potent, selective GPR55 antagonist with IC50 of 221 nM, shows >27-, >145- and >145-fold selectivity for GPR55 over CB1, GPR35 and CB2, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

ML193 (CID 1261822) is a potent, selective GPR55 antagonist with IC50 of 221 nM, shows >27-, >145- and >145-fold selectivity for GPR55 over CB1, GPR35 and CB2, respectively.
ML193 reduces neuronal differentiation in vitro, increases anxiety-like behaviors while causing locomotor impairment by i.c.v. injection at the doses of 0.1 and 1 μg/rat.

Physicochemical Properties

M.Wt 527.59
Formula C28H25N5O4S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-[4-[[(3,4-Dimethyl-5-isoxazolyl)amino]sulfonyl]phenyl]-6,8-dimethyl-2-(2-pyridinyl)-4-quinolinecarboxamide

References

1. Kotsikorou E, et al. Biochemistry. 2013 Dec 31;52(52):9456-69.

2. Munawar N, et al. Front Pharmacol. 2017 Mar 20;8:136.

3. Drzazga A, et al. Biochem Biophys Res Commun. 2017 Jul 22;489(2):242-247.

4. Hill JD, et al. Br J Pharmacol. 2018 Jun 11. doi: 10.1111/bph.14387.

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