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ML213

Chemical Structure : ML213

CAS No.: 489402-47-3

ML213 (ML-213, ML 213)

Catalog No.: PC-60228Not For Human Use, Lab Use Only.

ML213 is a potent, selective KCNQ2 (Kv7.2) and KCNQ4 (Kv7.4) activator with EC50 of 230 and 510 nM, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

ML213 is a potent, selective KCNQ2 (Kv7.2) and KCNQ4 (Kv7.4) activator with EC50 of 230 and 510 nM, respectively.
ML213 displays >80-fold selectivity over other related potassium channels (KCNQ1/3/5).
ML213 causes significant hyperpolarization in mesenteric artery smooth muscle cells, shows potent vasorelaxant effects in different blood vessels.

Physicochemical Properties

M.Wt 257.37
Formula C17H23NO
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-(2,4,6-Trimethylphenyl)-bicyclo[2.2.1]heptane-2-carboxamide

References

1. Yu H, et al. ACS Chem Neurosci. 2011 Oct 19;2(10):572-577.

2. Jepps TA, et al. Br J Pharmacol. 2014 Oct;171(19):4413-24.

3. Brueggemann LI, et al. Mol Pharmacol. 2014 Sep;86(3):330-41.

4. Provence A, et al. J Pharmacol Exp Ther. 2017 Oct 30. pii: jpet.117.243162.

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