Catalog No.: PC-38533Not For Human Use, Lab Use Only.
ML226 (ML-226) is a potent, selective, covalent inhibitor of α/β hydrolase domain-containing protein 11 (ABHD11) with IC50 values of 15 and 0.68 nM in vitro and in situ, respectively.
ML226 (ML-226) is a potent, selective, covalent inhibitor of α/β hydrolase domain-containing protein 11 (ABHD11) with IC50 values of 15 and 0.68 nM in vitro and in situ, respectively.
ML226 is 100-fold selective for ABHD11 over approximately 20 other serine hydrolases.
ML226 covalently carbamoylates the active site serine of ABHD11.
1. Hsu KL, et al. Optimization and characterization of triazole urea inhibitors for abhydrolase domain containing protein 6 (ABHD6). 2012 Apr 12 [updated 2013 Mar 14]. In: Probe Reports from the NIH Molecular Libraries Program [Internet].
