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Chemical Structure : ML226
CAS No.: 2055172-43-3
Catalog No.: PC-38533Not For Human Use, Lab Use Only.
ML226 is a potent, selective, covalent inhibitor of α/β hydrolase domain-containing protein 11 (ABHD11) with IC50 values of 15 and 0.68 nM in vitro and in situ, respectively.
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| 10 mg | $728 | In stock | |
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ML226 is a potent, selective, covalent inhibitor of α/β hydrolase domain-containing protein 11 (ABHD11) with IC50 values of 15 and 0.68 nM in vitro and in situ, respectively.
ML226 is 100-fold selective for ABHD11 over approximately 20 other serine hydrolases.
ML226 covalently carbamoylates the active site serine of ABHD11.
| M.Wt | 390.5 | |
| Formula | C23H26N4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(2-ethyl-1-piperidinyl)[4-(hydroxydiphenylmethyl)-2H-1,2,3-triazol-2-yl]-methanone |
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1. Adibekian, A.,et al. Anti-probe for LYPLA1/LYPLA2 dual inhibitor ML211. Probe Reports from the NIH Molecular Libraries Program (2010).
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