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ML236

Chemical Structure : ML236

CAS No.: 876713-68-7

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ML236 (ML-236)

Catalog No.: PC-38805Not For Human Use, Lab Use Only.

ML236 is a potent, B-cell specific NF-κB inhibitor with IC50 of 35 nM, selective for the NF-κB pathway induced by PKC activators (phorbol myristic acetate/ionomycin) and selective for B-cells.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    ML236 is a potent, B-cell specific NF-κB inhibitor with IC50 of 35 nM, selective for the NF-κB pathway induced by PKC activators (phorbol myristic acetate/ionomycin) and selective for B-cells.
    ML236 displays >400-fold selective over both the NF-κB activation in T-cells and against TNFα-mediated NF-κB activation.

    Physicochemical Properties

    M.Wt 287.363
    Formula C16H21N3O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    3-(3-(4-(tert-butyl)phenyl)-1,2,4-oxadiazol-5-yl)-N-methylpropanamide

    References

    1. Pu J, et al. In: Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010–.

    2. Lee HH, et al. Cancers (Basel). 2019 Dec 30;12(1):98.

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