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Chemical Structure : ML248
CAS No.: 1345858-76-5
Catalog No.: PC-73203Not For Human Use, Lab Use Only.
ML248 (CYM50308) is a potent and selective S1P4 receptor agonist with EC50 of 37.7 nM-79.1 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $158 | In stock | |
| 10 mg | $248 | In stock | |
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| 50 mg | Get quote | ||
| 100 mg | Get quote |
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ML248 (CYM50308) is a potent and selective S1P4 receptor agonist with EC50 of 37.7 nM-79.1 nM.
ML248 (CYM50308) is inactive as an agonist against other members of the receptor family, with EC50s >25 μM against S1P1, S1P2, and S1P3 receptors, and an EC50 of 2.1 μM against the S1P5 receptor.
ML248 (CYM50308) is inhibited by an S1P4 receptor-selective antagonist, inactive for agonism in the presence of >3.7 nM selective antagonist and is nontoxic to U2OS cells.
ML248 (CYM50308) increased expression of the chemokine receptor CXCR4 in compound treated CD8+ T lymphocytes.
| M.Wt | 405.46 | |
| Formula | C20H21F2N3O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(2Z,5Z)-5-((1-(2,4-Difluorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl)methylene)-2-((2-methoxyethyl)imino)-3-methylthiazolidin-4-one |
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1. Miguel Guerrero, et al. Probe Reports from the NIH Molecular Libraries Program [Internet].
2. Tobias Burkard, et al. Front Immunol. 2021 Aug 24;12:668884.
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