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ML252

Chemical Structure : ML252

CAS No.: 1392494-64-2

ML252 (ML 252 )

Catalog No.: PC-20943Not For Human Use, Lab Use Only.

ML252 is a potent and selective, brain penetrant inhibitor of KCNQ2 (Kv 7.2) with IC50 of 69 nM, EC50 of 170 nM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

ML252 is a potent and selective, brain penetrant inhibitor of KCNQ2 (Kv 7.2) with IC50 of 69 nM, EC50 of 170 nM.
ML252 is >40-fold selective versus KCNQ1.

Physicochemical Properties

M.Wt 308.43
Formula C20H24N2O
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

CC[C@@H](C1=CC=CC=C1)C(NC2=CC=CC=C2N3CCCC3)=O

References

1. Yiu-Yin Cheung, et al. J Med Chem. 2012 Aug 9;55(15):6975-9.

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