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ML253

Chemical Structure : ML253

CAS No.: 1417616-42-2

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ML253 (VU0448088)

Catalog No.: PC-24344Not For Human Use, Lab Use Only.

ML253 (VU0448088) is a potent, selective, CNS-penetrant M4 mAChR positive allosteric modulator (PAM) with EC50 of 56 nM (hM4) and 176 nM (rM4), selective against the four other muscarinic subtypes.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

ML253 (VU0448088) is a potent, selective, CNS-penetrant M4 mAChR positive allosteric modulator (PAM) with EC50 of 56 nM (hM4) and 176 nM (rM4), selective against the four other muscarinic subtypes.
ML253 is active in an amphetamine-induced hyperlocomotion assay.

Physicochemical Properties

M.Wt 346.83
Formula C16H15ClN4OS
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Thieno[2,3-b]pyridine-2-carboxamide, 3-amino-5-chloro-4,6-dimethyl-N-(4-pyridinylmethyl)-

References

1. Le U, et al. Bioorg Med Chem Lett. 2013 Jan 1;23(1):346-50.

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