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Chemical Structure : ML277
CAS No.: 1401242-74-7
Catalog No.: PC-42992Not For Human Use, Lab Use Only.
ML277 (CID53347902) is a potent and selective Kv7.1 (KCNQ1) potassium channel activator with EC50 of 260 nM, displays highly selectivity against other KCNQ channels (>100-fold selectivityover KCNQ2 and KCNQ4).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $78 | In stock | |
| 10 mg | $118 | In stock | |
| 25 mg | $188 | In stock | |
| 50 mg | $298 | In stock | |
| 100 mg | Get quote |
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ML277 (CID53347902) is a potent and selective Kv7.1 (KCNQ1) potassium channel activator with EC50 of 260 nM, displays highly selectivity against other KCNQ channels (>100-fold selectivityover KCNQ2 and KCNQ4).
ML277 potentiates both homomultimeric KCNQ1 channels and unsaturated heteromultimeric (KCNQ1)4(KCNE1)n (n < 4) channels.
ML277 effectively augments IKs current of cultured human cardiomyocytes and shortens action potential duration.
| M.Wt | 471.5923 | |
| Formula | C23H25N3O4S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 56 mg/mL |
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| Chemical Name/SMILES |
2-Piperidinecarboxamide, N-[4-(4-methoxyphenyl)-2-thiazolyl]-1-[(4-methylphenyl)sulfonyl]-, (2R)- |
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1. Mattmann ME, et al. Bioorg Med Chem Lett. 2012 Sep 15;22(18):5936-41.
2. Yu H, et al. Proc Natl Acad Sci U S A. 2013 May 21;110(21):8732-7.
3. Svalø J, et al. PLoS One. 2015 Feb 18;10(2):e0117350.
4. Kuusela J, et al. Stem Cell Rev. 2016 Dec;12(6):698-707.
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