ML 278 |CAS:1604821-43-3 Probechem Biochemicals

Chemical Structure : ML 278

ML 278 (ML278)

Catalog No.: PC-62104Not For Human Use, Lab Use Only.

ML278 is a potent and reversible inhibitor of lipid uptake via SR-BI (scavenger receptor BI) with IC50 of 6 nM.

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Biological Activity

ML278 is a potent and reversible inhibitor of lipid uptake via SR-BI (scavenger receptor BI) with IC50 of 6 nM.
ML278 is a plasma-stable, noncytotoxic probe that exhibits moderate metabolic stability, thus displaying improved properties for in vitro and in vivo studies.
ML278 increases the binding of HDL to SR-BI.

Physicochemical Properties

M.Wt	453.513
Formula	C23H23N3O5S
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	3,5-dimethoxy-N-(4-(1-(2-methoxyacetyl)indolin-5-yl)thiazol-2-yl)benzamide

References

1. Dockendorff C, et al. ACS Med Chem Lett. 2015 Feb 2;6(4):375-380.

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ML 278 (ML278)

Biological Activity

Physicochemical Properties

References

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